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lif inhibitor ec330  (MedChemExpress)


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    MedChemExpress lif inhibitor ec330
    CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding <t>EC330</t> in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.
    Lif Inhibitor Ec330, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lif+inhibitor+ec330/EC330/pmc12317280-29-0-6
    Average 93 stars, based on 8 article reviews
    lif inhibitor ec330 - by Bioz Stars, 2026-09
    93/100 stars

    Images

    1) Product Images from "CTHRC 1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF ‐ STAT 3 Pathway"

    Article Title: CTHRC 1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF ‐ STAT 3 Pathway

    Journal: Cancer Medicine

    doi: 10.1002/cam4.71126

    CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.
    Figure Legend Snippet: CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.

    Techniques Used: Activation Assay, Western Blot, Migration

    Related Articles

    Injection:

    Article Title: Multiple cancer cell types release LIF and Gal3 to hijack neural signals.
    Article Snippet: For the administration of recombinant mouse LIF (Thermo Fisher Scientific) or Gal3 (BioLegend), each mouse was intraperitoneally injected with the indicated amounts of the proteins in 100 μL sterile saline. .. For the treatment of the LIF inhibitor EC330 (MedChemExpress) or the Gal3 inhibitor GB1107 (MedChemExpress), tumor-bearing mice were daily administered with EC330 at 1 mg/kg of body weight or GB1107 at 5 mg/kg of body weight via intraperitoneal injection. .. For the treatment of sympathetic neurotransmitter NE (Sigma), tumorbearing mice were administered with NE at 1 mg/kg of body weight via intraperitoneal injection.

    Article Title: Multiple cancer cell types release LIF and Gal3 to hijack neural signals
    Article Snippet: For the administration of recombinant mouse LIF (Thermo Fisher Scientific) or Gal3 (BioLegend), each mouse was intraperitoneally injected with the indicated amounts of the proteins in 100 μL sterile saline. .. For the treatment of the LIF inhibitor EC330 (MedChemExpress) or the Gal3 inhibitor GB1107 (MedChemExpress), tumor-bearing mice were daily administered with EC330 at 1 mg/kg of body weight or GB1107 at 5 mg/kg of body weight via intraperitoneal injection. .. For the treatment of sympathetic neurotransmitter NE (Sigma), tumor-bearing mice were administered with NE at 1 mg/kg of body weight via intraperitoneal injection.

    other:

    Article Title: CTHRC 1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF ‐ STAT 3 Pathway
    Article Snippet: LIF inhibitor EC330 was purchased from MedChemExpress (MCE).

    Article Title: Cancer-Associated Fibroblasts Interact with Schwann Cells for Tumor Perineural Invasion by Oral Squamous Cell Carcinoma.
    Article Snippet: A nerve is supported and protected by three layers of connective tissue membranes (endoneurium, perineurium, and epineurium).. Schwann cells (SCs) and nerve fibroblasts (N-Fbs) play crucial roles in maintaining the physiological homeostasis of the peripheral nervous system.. SCs are a type of glial cell that wraps around axons; they are mainly found in the endoneurium and participate in the formation of nerve fibers.



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    CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding <t>EC330</t> in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.
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    Image Search Results


    CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.

    Journal: Cancer Medicine

    Article Title: CTHRC 1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF ‐ STAT 3 Pathway

    doi: 10.1002/cam4.71126

    Figure Lengend Snippet: CTHRC1 in CAFs mediates the activation of STAT3 signaling pathway in pancreatic cancer cells by positively regulating LIF. (A) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (B) Western Blot was used to detect the activation of STAT3 signaling pathway in Aspc‐1 after adding EC330 in CAFs‐CM and protein gray scale analysis. (C) Effect of CAFs‐CM on the proliferation function of Panc‐1 after adding EC330. (D) Effect of CAFs‐CM on the colony‐forming function of Panc‐1 after adding EC330. (E) Effect of CAFs‐CM on the migration function of Panc‐1 after adding EC330. (F, G) Western Blot was used to detect the activation of STAT3 signaling pathway in Panc‐1 after adding EC330 in CAFs‐CM overexpressing CTHRC1 and protein gray scale analysis. (H) Effect of CAFs‐CM overexpressing CTHRC1 on the proliferation function of Panc‐1 after adding EC330. (I, J) Effect of CAFs‐CM overexpressing CTHRC1 on the colony‐forming function of Panc‐1 after adding EC330. (K) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Panc‐1 after adding EC330. (L) Effect of CAFs‐CM on the proliferative function of Aspc‐1 after adding Stattic. (M) Effect of CAFs‐CM overexpressing CTHRC1 on the migration function of Aspc‐1 after adding Stattic. ** p < 0.01; *** p < 0.001.

    Article Snippet: LIF inhibitor EC330 was purchased from MedChemExpress (MCE).

    Techniques: Activation Assay, Western Blot, Migration